|
|||||
|
|
Delivery of immunotherapy with peptide-pulsed blood in macaques |
|
| Authors: | De Rose Robert Fernandez Caroline S Loh Liyen Peut Viv Mason Rosemarie D Alcantara Sheilajen Reece Jeanette Kent Stephen J |
| Affiliation: | Department of Microbiology and Immunology, University of Melbourne, 3010, Australia |
| Abstract: | Simple and effective delivery methods for cellular immunotherapies are needed. We assessed ex vivo pulsing of overlapping SIV Gag 15mer peptides onto either whole blood or PBMC in 15 randomly assigned SIV-infected macaques. Both delivery methods were safe and immunogenic, stimulating high levels of broad and polyfunctional Gag-specific CD4 and CD8 T cells. Delivery of overlapping Gag peptides via either whole blood or PBMC is suitable for clinical evaluation. |
| Keywords: | Peptides Overlapping Immunotherapy Blood Gag Vaccination SIV Macaques |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |