Three-dimensional preoperative maps of hippocampal atrophy predict surgical outcomes in temporal lobe epilepsy |
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| Authors: | Lin J J Salamon N Dutton R A Lee A D Geaga J A Hayashi K M Toga A W Engel J Thompson P M |
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| Affiliation: | Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. linjj@uci.edu |
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| Abstract: | The authors used surface-based anatomic mapping to detect features of hippocampal anatomy that correlated with surgical outcomes in patients undergoing surgery for mesial temporal lobe epilepsy with hippocampal sclerosis. Compared with a seizure-free group, hippocampal profiles for the non-seizure-free group had greater diffuse ipsilateral atrophy and more region-specific contralateral atrophy in the anterior, lateral hippocampus. These atrophic regions may indicate areas of increased epileptogenicity, contributing to poorer surgical outcomes. |
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