| T—2毒素致小型猪关节软骨的毒性实验研究 |
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| 引用本文： | 熊咏民 罗毅. T—2毒素致小型猪关节软骨的毒性实验研究[J]. 中国地方病防治杂志, 1997, 12(1): 4-6 |
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| 作者姓名： | 熊咏民 罗毅 |
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| 作者单位： | [1]西安医科大学地方性骨病研究所 [2]军事医学科学院六所 |
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| 摘 要： | 本研究表明Ｔ－２毒素对软骨组织具有较强的毒怀作用，能致小型猪关节软骨发生类似人类大骨节病样的深层坏死，并此起基质中蛋白聚糖代谢改变，硒能在一定程度上拮抗Ｔ－２毒素的作用。Ｔ－２毒素致小型猪关节软骨实验模型是与大骨节极类似的动物模型。Ｔ－２毒素与大骨节病的病因关节需作地一步的临充和病和实验室的验证。
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| 关 键 词： | T－2毒素 毒性试验 软骨坏死 大骨节病 蛋白聚糖 |
TOXIC EFFECT OF T-2 TOXIN ON ARTICULAR CARTILAGE IN CHINESE EXPERIMENTAL MINI-PIG |
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| Xiong Yongmin,et atInstitute of Endemic Bone Disease,Xi''''an Medical University. TOXIC EFFECT OF T-2 TOXIN ON ARTICULAR CARTILAGE IN CHINESE EXPERIMENTAL MINI-PIG[J]. Chinese Journal of Control of Endemic Disenaces, 1997, 12(1): 4-6 |
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| Authors: | Xiong Yongmin et atInstitute of Endemic Bone Disease Xi''''an Medical University |
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| Abstract: | Pathological observations and biological analyses were carried out on the articular cartilage of Chinese experimental mini-pig fed on T-2 toxin. The results showed that articular cartilage presented band or flake-shaped necrosis; and proteoglycans in the T-2 toxin group decreased compared with the control; and selenium can reduce the disease changes of articular cartilage and ameliorate the impairment of proteoglycans metabolism to some extent. These findings suggested that T-2 toxin had significant toxic effects on articular cartilage; and the structural changes of articular cartilage in mini-pig caused by T-2 toxin were nearly the same as KBD cartilage necrosis in human. It was also suggested to further study the etiological significance of T-2 toxin in KBD especially in the aspect of epidemiology. |
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| Keywords: | T-2 toxin Cartilage necrosis Chinese experimental mini-pig Kashin-Beck Disease Proteoglycan |
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