利培酮与氯氮平治疗精神分裂症各30例的比较

比较利培酮与氯氮平治疗精神分裂症的疗效和不良反应。方法 :男性精神分裂症 6 0例 ,分为利培酮组 30例 年龄 (2 8±s 6 )a ,病程 (5 .7± 1.6 )a],氯氮平组 30例 年龄 (2 8± 7)a ,病程 (5 .1± 1.6 )a],利培酮组给利培酮 ,开始 1～ 2mg·d- 1,2wk内加至 6～ 8mg·d- 1,氯氮平组给氯氮平 ,开始 5 0～10 0mg·d- 1,2wk内加至 30 0～ 4 0 0mg·d- 1,8wk为一个疗程。采用简明精神病量表 (BPRS)和副反应量表 (TESS)评定疗效和不良反应。结果 :利培酮与氯氮平组治疗精神分裂症总有效率均为 90 %(P >0 .0 5 ) ,2组治疗前、后BPRS评分差异有非常显著意义 (P <0 .0 1) ,2组治疗后TESS评分差异有显著意义 (P <0 .0 5 )。结论 :利培酮组与氯氮平组治疗精神分裂症疗效相当 ,但利培酮不良反应少。

Risperidone vs clozapine for treatment of schizophrenia in 30 patients each

AIM: To compare the efficacy and adverse reactions of risperidone and clozapine in the treatment of schizophrenia. METHODS:Sixty male patients with schizophrenia were divided into 2 groups. Thirty patients of risperidone group(age (28±s 6)a,course of disease(5.7±1.6)a)were treated with risperidone 1-2 mg·d -1 at first, then increased to 6-8 mg·d -1 according to the clinical effects and adverse reactions in 2 wk. Thirty patients of clozapine group (age(28±7)a, course of disease(5.1±1.6)a) were treated with clozapine 50-100 mg·d -1 at first, then increased to 300-400 mg·d -1 in 2 wk. The course of treatment were 8 wk. The effects and adverse reactions were rated with BPRS and TESS scale. RESULTS:The total effective rate were 90 % in both groups(P>0.05). The scores of BPRS before and after treatment in 2 groups were significanty difference(P<0.01). The scores of TESS after treatment in 2 groups were difference (P<0.05). CONCLUSION:Risperidone is effective and safe in treatment of schizophrenia as clozapine, but the adverse reactions are less than those of clozapine.