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| 金银花超微粉体不同极性部位的指纹图谱及其与抑菌活性相关性研究 | |
| 引用本文： | 张水寒,袁清照,蔡光先,冯小燕,邵怡.金银花超微粉体不同极性部位的指纹图谱及其与抑菌活性相关性研究[J].中草药,2011,42(11):2226-2230. |
| 作者姓名： | 张水寒 袁清照 蔡光先 冯小燕 邵怡 |
| 作者单位： | 1. 湖南省中医药研究院医药粉体技术教育部工程研究中心,湖南省中药粉体与创新药物省部共建国家重点实验室,湖南长沙410013 2. 湖南省中医药研究院医药粉体技术教育部工程研究中心,湖南省中药粉体与创新药物省部共建国家重点实验室,湖南长沙410013;湖南中医药大学,湖南长沙410007 3. 湖南中医药大学,湖南长沙,410007 |
| 基金项目： | 国家财政部社会公益类行业科研专项 |
| 摘 要： | 目的建立金银花超微粉体不同极性部位的指纹图谱,并研究其与抑菌活性的相关性。方法采用系统溶剂提取法得到6个不同极性部位,分别采用HPLC法进行测定,同时选择体外抑菌药理指标进行活性测定;用多元线性回归分析揭示化学信息与抑菌指标的相关关系,寻找与药理指标密切相关的物质群。结果确定以醋酸乙酯提取部位的HPLC指纹图谱来制定金银花的抑菌活性指纹图谱。结论应用该方法建立的金银花粉体的质量标准科学、合理、实用。 |
| 关 键 词： | 金银花 中药粉体 极性部位 HPLC 指纹图谱 抑菌活性 |
| 收稿时间： | 2011/2/16 0:00:00 |
Fingerprint of different polarity extracts from superfine powder of Lonicera japonica and its correlation of antibacterial activity |
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| ZHANG Shui-han,YUAN Qing-zhao,CAI Guang-xian,FENG Xiao-yan and SHAO Yi.Fingerprint of different polarity extracts from superfine powder of Lonicera japonica and its correlation of antibacterial activity[J].Chinese Traditional and Herbal Drugs,2011,42(11):2226-2230. | |
| Authors: | ZHANG Shui-han YUAN Qing-zhao CAI Guang-xian FENG Xiao-yan and SHAO Yi |
| Institution: | ZHANG Shui-han1,YUAN Qing-zhao1,CAI Guang-xian1,2,FENG Xiao-yan2,SHAO Yi2 1.Hunan Key Laboratory of Chinese Materia Medica Powder and Innovation Drug Province Department Co-construction,Engineering Research Center of Chinese Materia Medica Powder Technology,Ministry of Education,Hunan Academy of Chinese Medicine,Changsha 410013,China 2.Hunan University of Chinese Medicine,Changsha 410007,China |
| Abstract: | Objective To establish the fingerprint of Lonicera japonica superfine powder with different polarity and study its correlation of antibacterial activity.Methods Six different polarity extracts were obtained using the solvent system extraction and then were detected by HPLC with gradient elution.Pharmacological activities were detected by antibiotic indexes in vitro.The correlation between the pharmacological indexes and the information of HPLC fingerprint was discovered by multiple linear regression analysi... |
| Keywords: | Lonicera japonica Thunb Chinese materia medica powder polarity fraction HPLC fingerprint antibacterial activity |
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