| S-100A4和MMP-2在胃癌组织中的表达及意义 |
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| 引用本文： | 张丽媛,郑雄伟,林贤东,师怡,朱伟峰,林娜,何银珠,郑天荣. S-100A4和MMP-2在胃癌组织中的表达及意义[J]. 诊断病理学杂志, 2011, 18(5): 348-350,353. DOI: 10.3969/j.issn.1007-8096.2011.05.008 |
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| 作者姓名： | 张丽媛 郑雄伟 林贤东 师怡 朱伟峰 林娜 何银珠 郑天荣 |
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| 作者单位： | 福建医科大学教学医院福建省肿瘤医院病理科,福州,350014 |
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| 基金项目： | 卫生部科学研究基金资助(WKJ2008-2-43) |
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| 摘 要： | 目的通过检测S-100A4和基质金属蛋白酶2(MMP-2)在胃癌组织中的表达,探讨其在胃癌侵袭和转移中的作用。方法采用SP法检测S-100A4和MMP-2在91例胃癌组织以及91例配对切缘正常黏膜和72例转移淋巴结组织中的表达,分析其与胃癌临床病理特征的关系。结果 S-100A4在切缘正常黏膜、原发癌和淋巴结转移灶中的表达率分别为12.1%、29.7%和29.2%;MMP-2在相应组织中的表达率为20.8%、58.2%和59.7%。S-100A4和MMP-2在胃癌组织中表达均明显高于正常黏膜组织(P<0.05),而且其表达与肿瘤的浸润程度密切相关。S-100A4与MMP-2在胃癌组织中的表达呈正相关(r=0.27,P<0.05)。结论 S-100A4和MMP-2的表达与胃癌的侵袭密切相关,联合检测S-100A4和MMP-2表达有助于判定胃癌临床病理特征及预后。
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| 关 键 词： | 胃癌 S-100A4 MMP-2 免疫组化 |
Expression of S-100A4 and MMP-2 and their significance in gastric cancer |
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| Affiliation: | ZHANG Li-yuɑn,ZHENG xionɡ-wei,LIN Xiɑn-donɡ,ZHU Wei-fenɡ,LIN Nɑ,HE Yin-zhu,ZHENG Tiɑn-ronɡ(Department of Pathology,Fujian Province Tumor Hospital,Teaching Hospital of Fujian Medical University,Fuzhou 350014,China) |
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| Abstract: | Objective To investigate the expression of S100A4 and MMP-2 and their correlations to invasiveness and metastasis in gastric cancer.Methods Archival tissues from 91 patients with gastric cancer were retrieved.Matched samples including adjacent normal gastric tissues,primary tumor and metastasis lymph node tissues were investigated immunohistochemically.The correlations of S100A4 and MMP-2 protein expression with clinicopathologic factors were were analyzed.Results The positive rates of S100A4 protein in non... |
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| Keywords: | Gastric cancer S-100A4 MMP-2 Immunohistochemistry |
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