| GC法测定复方细胞色素C滴眼液中丁二酸钠含量 |
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| 引用本文： | 税庆华 于胜茂 潘继飞. GC法测定复方细胞色素C滴眼液中丁二酸钠含量[J]. 齐鲁药事, 2005, 24(10): 598-600 |
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| 作者姓名： | 税庆华 于胜茂 潘继飞 |
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| 作者单位： | [1]山东正大福瑞达制药有限公司,济南250014 [2]山东生化药物研究所,济南250014 |
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| 摘 要： | 目的建立了GC法测定复方细胞色素C滴眼液中丁二酸钠的含量。方法样品经酸化乙酸乙酯萃取,用三氟化硼-甲醇衍生后进行GC分析。内标为丙二酸二甲酯。结果方法线性关系良好(r=0.9997),平均回收率:99.57%,RSD:0.99%。结论此法可用于丁二酸钠含量测定。
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| 关 键 词： | 丁二酸钠 含量测定 气相色谱 |
| 文章编号： | 1672-7738(2005)10-0598-03 |
Determination of sodium succinate in Co- cytochrome C eye drops by GC |
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| Shui Qing-hua,Yu Sheng-mao,Pan Ji-fei. Determination of sodium succinate in Co- cytochrome C eye drops by GC[J]. qilu pharmaceutical affairs, 2005, 24(10): 598-600 |
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| Authors: | Shui Qing-hua Yu Sheng-mao Pan Ji-fei |
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| Abstract: | Objective To establish a GC method for determination of sodium succinate in Co-cytochrome C eye drops.Methods The sample was analysed by GC after extracting by ethyl acetate and derivatization with boron trifluoride-methanol,the internal standard was dimethylmalonate.Results The linear relation of the method was satisfactory(r=0.9997),the average recovery rate was 99.57% and RSD was 0.99%.Conclusion The mothod was suitable for determination of sodium succinate in Co-cytochrome C eye drops. |
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| Keywords: | Sodium succinate determination GC |
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