| 骨髓增生性疾病患者的血清TNFα及白细胞介素变化 |
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| 引用本文： | 崔为发,杨金平,李大启,张云波,王宝珍.骨髓增生性疾病患者的血清TNFα及白细胞介素变化[J].山东医药,2001,41(5):5-6. |
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| 作者姓名： | 崔为发 杨金平 李大启 张云波 王宝珍 |
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| 作者单位： | 1. 潍坊医学院附属医院
2. 复旦大学医学院附属中山医院 |
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| 摘 要： | 采用ELISA法或RIA法对26例骨髓增生性疾病（MPD）患者的肿瘤坏死因子（TNFα）、白细胞介素2－及其受体（IL－2／sIL-2R)、白细胞介素6及其受体（IL－6／sIL-6R)和β2－MD水平进行了检测。发现MPD患者血清IL－2、β2－MG显著高于正常对照组，TNFα有升高趋势，IL－6／sIL-6R水平与对照组无显著性差异。病情活动或转化为急性白血病时，IL－2／sIL-2R和β2－MG均显著升高，提示这三项指标可作为判断MDP病情活动的参数。
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| 关 键 词： | 骨髓增生性疾病 肿瘤坏死因子α 白细胞介素 TNFα |
| 修稿时间： | 2000年11月29 |
Changes of TNF |
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| Cui Weifa,Yang Jinping,Li Daqi,et al.Changes of TNF[J].Shandong Medical Journal,2001,41(5):5-6. |
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| Authors: | Cui Weifa Yang Jinping Li Daqi et al |
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| Abstract: | Serum TNFα and interleukins were measured in 26 patients withmyeloproliferative disorders（MPD）by ELISA or RIA method.Elavated IL-2 and β2-MG levels were found in MPD patients，TNFα was slightly increased.There were no difference of IL-6 and sIL-6R levels between MPD and normal controls.In progressive disease and particularly when transformation to acute leukemia occurred，high levels of IL-2，sIL-2R and β2-MG were found in all patients.These results suggest that IL-2，sIL-2R and β2-MG could be as a potential prognostic usefulness in the individual patients. |
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