鼻咽肌上皮细胞癌的临床病理特点及与EB病毒的关系

【目的】 分析鼻咽肌上皮细胞癌的临床及病理特征以及其与EB病毒的关系｡【方法】 对12例鼻咽肌上皮细胞癌进行临床､病理及随访观察,EBERS原位杂交及免疫组织化学标记｡【结果】 12例鼻咽肌上皮细胞癌患者中,男性患者7例,女性患者5例,男女比1.4:1;年龄24 ~ 65岁,中位年龄46岁｡影像学资料都显示鼻咽部有明显的结节状肿物,肌上皮细胞的标记:S-100､SMA､P63､CK14及上皮标记:CK､CKL､CKH在12例肌上皮细胞癌中表达有差异,但是所有的肌上皮细胞癌恒定表达至少一项肌上皮细胞和上皮细胞标记｡12例鼻咽肌上皮细胞癌EBERS 原位杂交结果均为阴性｡【讨论】 肌上皮细胞癌是一种低度恶性的肿瘤,发生在鼻咽部极少见,其病理形态虽然复杂多变,但也有其特征性的形态特征,免疫组织化学及EBERS 原位杂交有助于其诊断,在治疗上采用手术切除的基础上进行联合放射及化学治疗将有效地控制肿瘤的复发及转移｡

Myoepithelial Carcinoma of Nasopharynx:Clinicopathologic Features and Relationship with Epstein-Barr Virus

[Objective]To analyze the clinical and pathological characteristics of myoepithelial carcinoma of nasopharynx,as well as its relationship with Epstein-Barr virus.[Methods]We report twelve cases of myoepithelial carcinoma of nasopharynx,study its clinical,histopathologic,and immunohistologic features,follow-up data and EBERS in-situ hybridization.[Results]Among age of patients ranged from 24 to 65 years(mean age=46 years).Imagery data demonstrated an extensive nodosity filling the nasopharynx,Of these 12 cgses,myoepithelial markers such as S-100,SMA,P63,CK14,CK5/6 and epithelial markers such as CK,CKL,CKH were not always all expressed at one case,but at less one of these two kind of markers expressed at one cage.The results of EBERS in-situ hybridization of 12 cases were negative.[Conclusion]Myoepithelial carcinoma is a low malignat tumor.It seldom takes place in nasopharynx,dispite its morphologic heterogeneity it has some special morphologic and immuohistologic characteristics as well as special result of EBERS in-situ hybridization,which may support its diagnosis.The combinde radiotherapy and chemotherapy after surgical removal of the tumor will control the recurrence and metabasis effectively.