| 丙戊酸群体药代动力学研究进展 |
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| 引用本文： | 李新林,赵明明,姜力,肇丽梅.丙戊酸群体药代动力学研究进展[J].实用药物与临床,2014(3):345-349. |
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| 作者姓名： | 李新林 赵明明 姜力 肇丽梅 |
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| 作者单位： | [1]中国医科大学附属盛京医院药学部,沈阳110004 [2]中国人民解放军第二O二医院泌尿科,沈阳110003 |
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| 基金项目： | 辽宁省自然科学基金项目（2013021078） |
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| 摘 要： | 丙戊酸是广谱抗癫疒间药,临床应用广泛。该药体内代谢个体差异大,治疗窗窄,需要个体化治疗。丙戊酸体内代谢受多种因素影响,大量研究报道了丙戊酸群体药代动力学参数及其在个体化治疗中的应用。本文分别从人口学因素、遗传因素及合并用药等方面,对丙戊酸群体药代动力学研究及应用进行综述,为临床制定合理、安全的给药方案提供参考。
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| 关 键 词： | 丙戊酸 基因多态性 合并用药 群体药代动力学 |
Progress in population pharmacokinetic of valproic acid |
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| LI Xin-lin,ZHAO Ming-ming,JIANG Li,ZHAO Li-mei.Progress in population pharmacokinetic of valproic acid[J].Practical Pharmacy and Clinical Remedies,2014(3):345-349. |
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| Authors: | LI Xin-lin ZHAO Ming-ming JIANG Li ZHAO Li-mei |
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| Institution: | 1. (1. Department of Pharmacy, Shengjing Hospital of China Medical University, Shenyang 110004, China; 2. Department of Urological Surgery, The 202th Hospital of PLA, Shenyang 110003, China) |
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| Abstract: | Valproic acid （VPA） is a broad-spectrum anti-epileptic drugs,widely used in clinical therapy. The individual treatment is useful for VPA because of the significant inter-individual differences in metabolism and its nar- row therapeutic index. VPA metabolism is affected by many factors, studies have reported a population pharmacokinet- ics parameters of VPA in individual treatment and their clinical application. This paper reviews the population pharma- cokinetics of VPA and its application from demographic factors, genetic factors and concomitant medications, for the clinical development of rational and safe dosing regimen for reference. |
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| Keywords: | Valproic acid Genetic polymorphism Combined medication Population pharmacokinetic |
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