胰腺癌早期诊断的现状与进展

胰腺癌是一种侵袭性较强的恶性肿瘤,通常预后较差。早期发现胰腺癌是改善预后的惟一方法,但只有少数病人可被早期诊断,并得到根治性切除。针对高危人群,特别是有家族史的人群进行筛查,将有助于胰腺癌的早期诊断。影像学诊断手段,包括内镜超声、胰管内超声和经口胰管镜检查也有利于早期发现胰腺癌。密切观察并治疗侵袭性胰腺癌的前提病变,从而降低胰腺癌的发生。目前,胰腺癌分子标志物的敏感性和特异性较差,不能用于大规模的人群筛查。

Advances in early diagnosis of pancreatic cancer

Pancreatic carcinoma is one of the most aggressive malignant tumors and generally has an extremely poor prognosis. Early detection of the disease is believed to be the only way to improve the prognosis because only a small percentage of patients are respectable at the time of diagnosis and have the possibility of being cured by radical resection. Screening of high-risk groups especially in patients with a family history is feasible to make a early diagnosis of pancreatic cancer. Imaging modalities including endoscopic ultrasonography (EUS), intraductal ultrasonography (IDUS), peroral pancreatoscopy (POPS) hold much promise for early diagnosis of pancreatic cancer. Identificating precursors to invasive pancreatic cancer can offer new targets for early detection. Current clinical pancreatic tumor markers lack the sensitivity and specificity required for screening an asymptomatic population for the purpose of early detection .Molecular markers of early pancreatic cancer need further investigation.