| 二硫化碳对大鼠F_2代后遗影响的研究 |
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| 引用本文： | 陈国元,杨克敌,张招弟,鲁翠荣,李学贵,黄红,田国钧.二硫化碳对大鼠F_2代后遗影响的研究[J].华中科技大学学报(医学版),1991(1). |
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| 作者姓名： | 陈国元 杨克敌 张招弟 鲁翠荣 李学贵 黄红 田国钧 |
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| 作者单位： | 同济医科大学公共卫生学院工业毒理研究室
(陈国元，杨克敌，张招弟，鲁翠荣)，河南省新乡市职业病防治所
(李学贵，黄红)，河南省新乡市职业病防治所(田国钧) |
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| 摘 要： | 本文报道大鼠妊娠7～14d以Cs_2染毒对F_2代的后遗影响。结果表明,CS_2对F_2代生长发育指标及F_1代脏器系数无明显影响,但对胎鼠有致畸作用,并可延续到第二代,以骨骼畸形为主,主要为胸骨缺失,其次为枕骨骨化延缓、肋骨延长和囱门增大等,且发生率几乎同胎鼠的F_1代。由此认为CS_2对后代的影响,主要是对F_2代的致畸作用较明显。
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| 关 键 词： | 二硫化碳类 致畸胎物 F_2代 遗传 |
Teratogenic Effects of Carbon Disulfide in F_2 Rat |
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| Chen Guoyuan,Yang Kedi,Zhang Zhaodi,Lu Cuirong Institute of Industrial Toxicology,School of Public Health,Tongji Medical University,Wuhan Li Xuegui,Huang Hong,Tian Guojun Institute of Occupational Disease,Xin Xiang,Henan Province.Teratogenic Effects of Carbon Disulfide in F_2 Rat[J].Journal of Huazhong University of Science and Technology(Health Sciences),1991(1). |
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| Authors: | Chen Guoyuan Yang Kedi Zhang Zhaodi Lu Cuirong Institute of Industrial Toxicology School of Public Health Tongji Medical University Wuhan Li Xuegui Huang Hong Tian Guojun Institute of Occupational Disease Xin Xiang Henan Province |
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| Abstract: | The teratogenic effects of CS2 in F2 rats were studied. It was found that CS2 caused sternum deletion, occipital bone growth retardation, ribs lengthening and coronale enlargement in F2 rats. However, no change whatever was found in growth and development of F2 rats and in organ coefficients of F, rats. From the above it may be concluded that by the teratogenic effects are meant mainly the toxic effects of CS2 on F2 rats. |
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| Keywords: | carbon disulfide teratogens F2 generation heredity |
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