内皮损伤在血管性疾病发生发展中的作用

内皮细胞功能异常与早期的血管病变紧密相关。内皮细胞功能的丧失是一系列损伤因素的结果,包括剪切力、药物诱导的毒性反应、免疫介导细胞在内的各种刺激因素是其启动因素。特异性因子介导的自身性免疫是内皮损伤的主要机制。局部炎性细胞因子和趋化因子的释放,激活内皮细胞上调黏附分子,使中性粒细胞产生过多的活性氧分子,扩大了炎性反应,导致细胞凋亡以及坏死。由于内皮细胞在血管壁损伤中的作用,作为血管损伤性疾病发展过程中的生物标记物对于新药的发现和血管损伤病因学的研究就显得极为重要。

Role of endothelial injury in initiation and progression of vascular disease

Endothelial dysfunction is closely related to early vascular disorders.Loss of endothelial function is the results a serial of injurious factors,including hemodynamic changes,drug-induced cytotoxicity and immune-mediating cell.Auto-immunal reaction mediated by specific factors is the major mechanism underlying endothelial damage.The local release of inflammatory factors and chemokines enhances the expression of adhesion molecules,therefore elicits excessive reactive oxygen,and escalates inflammatory reactio...