纳米人工骨混合自体骨治疗骨肿瘤及骨病43例

背景：纳米人工骨是一种新型的骨移植材料，具有良好生物相容性等优势，但其治疗骨肿瘤及骨病的临床效果尚有待进一步研究。 目的：回顾性分析纳米人工骨混合自体骨治疗骨肿瘤及骨病的临床效果。 方法：对43例骨肿瘤及骨病患者病灶进行彻底刮除，选用大小不一的纳米人工骨条或颗粒混合人工骨充填，并用尽量将腔隙填满压实。病理性骨折的4例患者行内固定，其余患者未行内固定，依病情选择适当的支具。观察植骨后患者全身状态及植骨局部情况，术后不同时间X射线片观察植骨局部情况。 结果与结论：43例患者均获随访，最短为6个月，最长为24个月。1例患者切口延迟愈合。余患者全身状态及切口愈合均良好。术后1~3个月纳米人工骨混合人工骨植入区与缺损周围的骨组织之间界限模糊，但局部仍可见密度高影。约12个月植入骨区与周围骨组织密度相似。结果证实应用纳米人工骨混合人工骨治疗骨肿瘤及骨病效果满意，且并发症较少，其为一种比较理想的移植骨替代物，且具有良好应用前景。 关键词：纳米人工骨；自体骨；骨肿瘤；骨病；骨组织工程 doi:10.3969/j.issn.1673-8225.2010.25.027

Nano-artificial bone mixed with autologous bone for treatment of bone tumors and bone disease in 43 cases

BACKGROUND: As a new bone graft, nano-artificial bone has many good qualities such as good biocompatibility, but the clinical effect in treating bone tumors and bone disease needs more studies. OBJECTIVE: To evaluate the clinical results of nano-artificial bone combined with autologous bone in treating bone tumors and bone disease. METHODS: A total of 43 patients with bone tumors and bone disease were implanted with nano-artificial bone or particles mixed with autologous bone after deleting tumor tissue, with lacune filling as much as possible. Four cases with pathologic fracture received internal fixation, while other cases had an orthosis. The postoperative complications of the whole body and the operation region were observed, and the X-ray films were observed to evaluate the bone healing at different time. RESULTS AND CONCLUSION: All 43 cases were followed up for average 6-24 months. Except one patient was delayed in wound healing, the other patients achieved good healing and general conditions. At 1-3 months postoperation, nano-artificial bone mixed with autologous bone graft began to fuse with bone tissue around defects, but increased density could be seen in local lesion. At 12 months, the bone graft region had a smilar density with the surronding bone tissues. The nano-artificial bone combined with autologous bone has been proved to be an ideal bone graft substitute material due to good results in the treatment of bone tumors and bone disease, and fewer complications. It has a good prospect of application.