Thrombocytopenia in Plasmodium falciparum, Plasmodium vivax and mixed infection malaria: a study from Bikaner (Northwestern India) |
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| Authors: | Kochar Dhanpat Kumar Das Ashis Kochar Abhishek Middha Sheetal Acharya Jyoti Tanwar Gajanand Singh Gupta Anjana Pakalapati Deepak Garg Shilpi Saxena Vishal Subudhi Amit Kumar Boopathi P A Sirohi Parmendra Kochar Sanjay Kumar |
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| Institution: | Department of Medicine, Kothari Medical & Research Institute, Bikaner, India. drdkkochar@yahoo.com |
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| Abstract: | The occurrence, relation and magnitude of thrombocytopenia in different species of malaria are not clearly defined. This study included 1,064 patients admitted with malaria to study thrombocytopenia (platelet count <150,000 /cumm) in Plasmodium falciparum (Pf) and Plasmodium vivax (Pv) mono infection and mixed infection (Pf?+?Pv). The species diagnosis was done by peripheral blood film (PBF) and rapid diagnostic test (RDT). Validation by polymerase chain reaction (PCR) was done only in patients with severe thrombocytopenia (platelet count <20,000 /cumm). The breakup of patients was 525 (49.34%) Pf, 460 (43.23%) Pv and 79 (7.42%) mixed malaria (Pf?+?Pv). Thrombocytopenia was observed in 24.6% (262/1064) patients. The risk was greatest in the mixed infections in comparison to monoinfection individually (43.04% 34/79]; mixed vs Pv monoinfection: Odds Ratio OR]?=?1.675 95% Confidence Interval (CI) 1.029-2.726], p?
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