电针结合经颅磁刺激抗焦虑协同效应的行为学研究

目的:研究电针结合经颅磁刺激对焦虑模型大鼠的抗焦虑协同效应.方法:采用SPS(Single Prolonged Stress)方法建立焦虑动物模型,运用电针结合经颅磁刺激进行治疗,采用高架十字迷宫和旷场实验测试动物情绪反应,观察电针结合经颅磁刺激抗焦虑协同效应.结果:在OT%值(A)、OE%值(B)、探头次数(C)、站...

Effects of Electric Acupuncture Combined with TMS on Emotions in Rat Model of Anxiety

Objective: The aim of this study was to investigate the effects of electric acupuncture combined with rTMS on emotions in rat model of anxiety following SPS stress.Methods: Fifty male rats were randomly divided into 5 groups:the empty group(K) 、the model group(M)、the model group accepted electric acupuncture treatment(Z)、the model group accepted rTMS treatment(C) 、the model group accepted both electric acupuncture and rTMS treatment(CZ).Rats were subjected to SPS stress,the next day they accepted different treatment in each group,groupZ used electric acupuncture on Baihui point(DU20) and Changqiang point(DU1),groupC used high-frequency(18.3Hz) rTMS,the stimulation consisted of 25 trains of 16 pulses,group CZ used both electric acupuncture and rTMS treatment.Once per day,keep on 3 days.Elevated plus maze test and open field test were performed.Results: 1.OT% and OE% were more in groupZ/groupC/groupCZ/ than in groupM,detecting head behavioral could be more observed in groupC/groupCZ than in groupM,standing behavioral could be more observed in groupCZ than in groupM/groupZ.2.Horizontal movements and vertical movements were both more in groupCZ than in groupM,vertical movements were more in groupZ/ groupK.Conclusion: 1.Both electric acupuncture and high-frequency rTMS could reduce emotional reaction and so dose the electric acupuncture combined with rTMS.2.Compared with groupZ/groupC,groupCZ showed more dominance.