| DC-SIGN/DC-SIGNR基因多态性与病原微生物感染 |
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| 引用本文： | 许利军,潘晨,李勤光. DC-SIGN/DC-SIGNR基因多态性与病原微生物感染[J]. 国际流行病学传染病学杂志, 2010, 37(1). DOI: 10.3760/cma.j.issn.1673-4149.2010.01.017 |
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| 作者姓名： | 许利军 潘晨 李勤光 |
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| 作者单位： | 福建医科大学附属福州市传染病医院肝病研究所,350025;福建医科大学附属福州市传染病医院肝病研究所,350025;福建医科大学附属福州市传染病医院肝病研究所,350025 |
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| 基金项目： | 福建省自然科学基金,福建省青年科研基金 |
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| 摘 要： | DC-SIGN和DC-SIGNR是两种表达于DC表面的蛋白,被认为是许多病原微生物的黏附受体,参与很多病原微生物的感染.DC-SIGN和DC-SIGNR(DC-SIGN/DC-SIGNR)的多态性或许影响病原微生物的感染过程和结果.此文对DC-SIGN/DC-SIGNR的结构功能以及与HIV、HCV感染、肺结核、登革热的关系进行了综述.
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| 关 键 词： | 病原 DC-SIGN 受体 多态性 感染 |
Polymorphisms of DC-SIGN/DC-SIGNR and pathogen infection |
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| XU Li-jun,PAN Chen,LI Qin-guang. Polymorphisms of DC-SIGN/DC-SIGNR and pathogen infection[J]. International Journal of Epidemiology and Infectious Disease, 2010, 37(1). DOI: 10.3760/cma.j.issn.1673-4149.2010.01.017 |
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| Authors: | XU Li-jun PAN Chen LI Qin-guang |
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| Abstract: | DC-SIGN and DC-SIGNR are two surface proteins on dendritic cells with complex stmction, and are regarded as attachment receptors of many pathogens, DC-SIGN/DC-SIGNR participate in pathogen infection.Polymorphisms of DC-SIGN/DC-SIGNR probably influence the procedure and outcome of pathogen infection. In this article, the structure and function of DC-SIGN/DC-SIGNR are discussed as well as the relation between the DC-SIGN/DC-SIGNR and pathogens such as HIV, HCV infection, pulmonary tuberculosis, dengue fever. |
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| Keywords: | DC-SIGN |
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