110例男性不育患者染色体异常核型临床分析

目的:对110例男性染色体核型进行临床分析,探讨男性染色体畸变与其表型效应的关系。方法:外周血淋巴细胞培养,染色体常规G显带分析。结果:110例男性外周血染色体异常核型中常染色体结构异常占23.6%;性染色体数目异常占70.0%;性染色体结构异常占6.4%。男性染色体异常核型中无精子症占68.2%少精症占2.7%;配偶有反复自发流产、生育死胎、畸胎占29.1%。110例男性染色体异常核型涉及除19、20号染色体外其他染色体。结论:染色体畸变是导致男性不育的重要因素,对久治不愈的不孕不育应检查染色体以排除染色体畸变的可能。

Clinical Analysis of Chromosomal Abnormality of 110 Cases of Male Patients with Infertility

Objective:To study the relationship between chromosome aberrances and their phenotype effect by clinical karyotype analysis of 110 cases of male patients with infertility.Methods:Peripheral blood lymphocyte culture and conventional chromosome analysis by G-band were conducted.Results:In 110 cases of male patients with chromosome aberrance,abnormal euchromosome structure accounted for 23.6%.The number of sex chromosome abnormalities and abnormal sex chromosome structure accounted for 70.0% and 6.4%,respectively.Among these cases patients with azoospermia and oligospermia were 68.2% and 2.7%,respectively.To their spouses,repeatedly spontaneous abortion,fetal death,terata accounted for 29.1%.Chromosome karyotype abnormalities were showed except the 19th and 20th Chromosome among 110 cases.Conclusion:Chromosome aberrance plays an important role in male infertility.Chromosome examination should be performed to exclude the possibility of chromosome aberrances in patients with obstinate infertility.