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| DAC包囊树脂血液灌流对阿霉素的吸附研究 | |
| 引用本文： | 杜祥楠 钮振. DAC包囊树脂血液灌流对阿霉素的吸附研究[J]. 生物医学工程学杂志, 1992, 9(1): 19-22 |
| 作者姓名： | 杜祥楠 钮振 |
| 作者单位： | 重庆医科大学人工肝研究室，重庆医科大学人工肝研究室，重庆医科大学人工肝研究室 重庆 630042，重庆 630042，重庆 630042 |
| 摘 要： | 本文探讨二乙酰化甲壳素包囊树脂(DAC包囊树脂)血液灌流对阿霉素的清除作用。实验分为体内及体外两部分。体外动态吸附试验比较了包括DAC包囊树脂在内的四种吸附剂对阿霉素的吸附性能,结果显示DAC包囊树脂吸附效果最佳。体内实验资料同样显示DAC包囊树脂对阿霉素的良好吸附性,大鼠经肠系膜静脉一次性注射阿霉素(5mg/kg)后。在血液流速为1ml/min的灌流条件下,经吸附2、30、60 min时,其阿霉素的廓清率分别达0.99、0.82、0.73 ml/mim。 |
| 关 键 词： | DAC包囊树脂 血液 阿霉素 吸附 |
Effect of Hemoperfusion with DAC-Coated Resin on Adriamycin Adsorption |
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| Du Xiangnan Niu Zhen Liu Yuhu. Effect of Hemoperfusion with DAC-Coated Resin on Adriamycin Adsorption[J]. Journal of biomedical engineering, 1992, 9(1): 19-22 | |
| Authors: | Du Xiangnan Niu Zhen Liu Yuhu |
| Affiliation: | Artificial Liver Research Laboratory Chongqing University of Medical Sciences |
| Abstract: | Effect of hemoperfusion on removal of adriarnycin in vitro and in vivo was studied. Adriamycin adsorption to four sorbents, DAC-coated resin, cross-linked agarose coated activated charcoal, NK-110 resin and uncoated activated charcoal was determined in vitro in a plasma solution. DAC-coated resin was most effective in removing adriamycin. Hemo perfusion of DAC-coated resin was performed in rats with intra-portal injection of adriamycin. Results of in vivo study also demonstrated efficient removal of adriamyein by DAC-coated resin. With hemoperfusion, mean clearances were 0.99ml/min, 0.82ml/min and 0.72ml/min at 2min, 30min and 60min respectively. It is suggested that hemoperfusion of DAC-coated resin be useful in reducing blood levels of adriamycin in patients with hepatocellular carcinoma. |
| Keywords: | Adriamycin Adsorption Hemoperfusion DAC-coated resin |
| 本文献已被 CNKI 维普 等数据库收录！ | |