| 乳腺康胶囊对乳腺增生大鼠乳腺组织和性激素的影响 |
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| 引用本文： | 李卫民,李廷冠,李敏江,尹雪曼,秦明芳. 乳腺康胶囊对乳腺增生大鼠乳腺组织和性激素的影响[J]. 中成药, 2003, 25(10): 817-819 |
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| 作者姓名： | 李卫民 李廷冠 李敏江 尹雪曼 秦明芳 |
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| 作者单位： | 1. 广西中医学院,广西,南宁,530001
2. 广西中医学院第二附属医院,广西,南宁,530011 |
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| 摘 要： | 目的 :观察乳腺康胶囊对乳腺增生大鼠性激素和乳腺组织的影响。方法 :采用苯甲酸雌二醇和黄体酮肌注造模30d后 ,分别用三苯氧胺和乳腺康治疗 30d ,同时继续肌注雌二醇。结果 :乳腺康胶囊、三苯氧胺可缩小乳腺增生病大鼠乳腺体积 ,减少乳腺小叶腺泡数、分泌物 (均P <0 .0 1) ,缩小腺泡腔 (P <0 .0 5 ) ;并使血清孕酮 (P)和睾酮 (T)水平降低(P <0 .0 5 )。结论 :乳腺康胶囊可通过调节乳腺增生大鼠的性激素水平 ,改善增生乳腺的形态学变化而有效地对抗雌激素引起的大鼠乳腺增生
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| 关 键 词： | 乳腺康胶囊 乳腺增生病 性激素 大鼠 |
| 文章编号： | 1001-1528(2003)10-0817-03 |
| 修稿时间： | 2002-10-09 |
Effect of Ruxiankang Capsules on mammary gland and sex hormone of rat with mastoplasia |
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| LI Wei min ,LI Ting guan ,LI Min jiang ,YIN Xue man ,QIN Ming fang. Effect of Ruxiankang Capsules on mammary gland and sex hormone of rat with mastoplasia[J]. Chinese Traditional Patent Medicine, 2003, 25(10): 817-819 |
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| Authors: | LI Wei min LI Ting guan LI Min jiang YIN Xue man QIN Ming fang |
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| Affiliation: | LI Wei min 1,LI Ting guan 2,LI Min jiang 2,YIN Xue man 2,QIN Ming fang 2 |
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| Abstract: | Objective: To observe the effect of Ruxiankang (RXK) Capsule (Radix Bupleuri, Poria, Rhizoma Atractylodis macrocephalae, Radix Angelicae Sinensis, Radix Paeoniae Alba, Rhizoma Cyperi, etc.) on mammary gland and sex hormone of rat with mastoplasia. Methods: After benzoate estradiol and progestogen were injected into rats for 30 days the mastoplasia model was made, the model rats were treated with tamoxifen and RXK Capsule for 30days, and injected estradiol at the same time. Results: RXK Capsule and tamoxifen could significantly inhibit HMG rat's mammary gland swell, reduce quantity of lobule alveolus in mammary glands and secretion ( P < 0.01 ), shrink lobule alveolus cavity ( P <0.05). RXK Capsule could also reduce progestogen and testosterone level ( P <0.05). Conclusion:RXK Capsule can antagonize rat's mastoplasia induced by benzoate estradiol through adjusting sex hormone level and ameliorating the histology change of hyperplasia's mammary gland. |
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| Keywords: | Ruxiankang Capsule mastoplasia sex hormone rat |
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