代谢综合征对中青年高血压患者颈动脉内膜中层厚度的影响

[目的]探讨代谢综合征(MS)对中青年原发性高血压(EH)患者颈动脉内膜中层厚度(IMT)的影响。[方法]将168例中青年EH患者按是否合并MS分为MS组(88例)和非MS组(80例),采用超声检测仪测定颈动脉IMT,同时测定体质指数(BMI)、腰围(WC)、收缩压(SBP)、舒张压(DBP)、空腹血糖(FPG)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)等相关数据进行比较。[结果]MS组的BMI、WC、FPG、TC、TG、LDL-C、IMT均明显高于非MS组,而HDL-C明显低于非MS组(P值均<0.05)。多因素Logistic回归分析显示,年龄、SBP、FPG、LDL-C为颈动脉IMT增厚的相关因素。[结论]MS对中青年EH患者的IMT有显著影响,其与高血压共同参与动脉粥样硬化过程,在治疗中除降低血压外,还要及早纠正代谢紊乱,预防动脉硬化引起并发症。

Influence of metabolic syndrome on carotid intima-media thickness in young and middle-aged patients with essential hypertension

[Objective] To evaluate the influence of metabolic syndrome (MS) on carotid intima-media thickness (IMT) in essential hypertension (EH).[Methods] A total of 168 young and middle-aged EH patients were divided into MS group (88 cases) and non-MS group (80 cases). Between the two groups were measured and compared IMT,body mass index (BMI),waist circumference (WC),systolic blood pressure (SBP),diastolic blood pressure (DBP), fasting plasma glucose (FPG),total cholesterol (TC),triglyceride (TG),high-density lipoprotein (HDL-C),low-density lipoprotein (LDL-C) and others. [Results] Comparison between MS group and non-MS group showed that the level of BMI, FPG, WC, TC, TG, LDL-C and IMT were higher in MS group,P all<0.05. Multiple Logistic regression analysis showed that age,SBP,FPG and LDL-C were the related factors for carotid IMT.[Conclusion] MS is associated with carotid IMT in young and middle-aged patients with EH. MS and EH may jointly participate in the process of atherosclerosis. Apart from control of blood pressure,correction of metabolic disorders is also necessary in order to prevent complication of atherosclerosis.