| 反常性痤疮发病机制的研究进展 |
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| 引用本文： | 仓田,王宝玺,渠涛. 反常性痤疮发病机制的研究进展[J]. 国外医学:皮肤性病学分册, 2012, 0(6): 373-375 |
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| 作者姓名： | 仓田 王宝玺 渠涛 |
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| 作者单位： | [1]中国医学科学院北京协和医学院皮肤病研究所,南京210042 [2]中国医学科学院北京协和医学院北京协和医院皮肤科,南京210042 |
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| 基金项目： | 国家自然科学基金（81171522） |
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| 摘 要： | 反常性痤疮是一种慢性化脓性毛囊炎症，以反复发生疼痛性皮肤脓肿、窦道及瘢痕形成为特征。常发生于青春期后，可呈家族性或散发。反常性痤疮的发病机制目前尚未阐明，可能是由遗传因素、免疫因素、吸烟、肥胖、雄激素等多种因素共同作用的结果。部分家族性反常性痤疮的发病是编码吖一分泌酶不同亚单位的基因发生功能缺失突变引起的。
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| 关 键 词： | 反常性痤疮 发病机制 y-分泌酶 雄激素类 |
Advances in the pathogenesis of acne inversa |
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| CANG Tian; WANG Bao-xi,QU Tao. Advances in the pathogenesis of acne inversa[J]. Foreign Medical Sciences(Section of Dermatology and Venereology), 2012, 0(6): 373-375 |
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| Authors: | CANG Tian WANG Bao-xi,QU Tao |
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| Affiliation: | . Institute ofDermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China |
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| Abstract: | Acne inversa （AI） is a chronic purulent folliculitis characterized by recurrent painful skin abscesses, draining sinuses, and disfiguring scars. AI typically occurs after puberty and can be either familial or sporadic. The pathogenesis of AI remains unanswered, and is considered to be associated with genetic predisposition, aberrant immunity, smoking, obesity and androgens. Recently, it has been evidenced that loss- of-function mutations in genes encoding y-secretase components contribute to the development of AI in some patients. |
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| Keywords: | Acne inverse Pathogenesis y-Secretase Androgens |
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