Visfatin与代谢综合征

visfatin是一种新的脂肪细胞因子,主要由内脏脂肪分泌;visfatin能与胰岛素受体直接结合,发挥胰岛素样作用。visfatin呈结晶状结构,受到激素、噻唑烷类二酮药物、游离脂肪酸、葡萄糖、运动和缺氧等多种因素的调节。visfatin基因本身并不是2型糖尿病和肥胖的主要敏感性基因,但它可能在葡萄糖和脂质代谢中发挥作用。visfatin与胰岛素抵抗、肥胖、糖尿病和脂代谢异常等代谢紊乱密切相关,提示visfatin可能在代谢综合征的发病机制中起着重要的作用。

Visfatin and Metabolic Syndrome

Visfatin is a novel adipocytokine mainly secreted by visceral adipose tissue.It can bind to the insulin receptor and exert insulin-like effects.It has crystal structure and can be regulated by various factors such as hormones,thiazolidinediones,free fatty acids,glucose,sports,hypoxia and so on.Visfatin gene itself is not the main sensitive gene of type 2 diabetes mellitus and obesity,but it maybe play the important role in glucose and lipid metabolism.It is strongly associated with metabolic disturbances su...