Dopamine and inhibitory action control: evidence from spontaneous eye blink rates |
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| Authors: | Lorenza Serena Colzato Wery P M van den Wildenberg Nelleke C van Wouwe Merel M Pannebakker and Bernhard Hommel |
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| Institution: | (1) Cognitive Psychology Unit, Department of Psychology, Leiden Institute for Brain and Cognition, Leiden University, Postbus 9555, 2300 RB Leiden, The Netherlands;(2) Psychology Department, Amsterdam Center for the Study of Adaptive Control in Brain and Behaviour (Acacia), Universiteit van Amsterdam, Amsterdam, The Netherlands |
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| Abstract: | The inhibitory control of actions has been claimed to rely on dopaminergic pathways. Given that this hypothesis is mainly
based on patient and drug studies, some authors have questioned its validity and suggested that beneficial effects of dopaminergic
stimulants on response inhibition may be limited to cases of suboptimal inhibitory functioning. We present evidence that,
in carefully selected healthy adults, spontaneous eyeblink rate, a marker of central dopaminergic functioning, reliably predicts
the efficiency in inhibiting unwanted action tendencies in a stop-signal task. These findings support the assumption of a
modulatory role for dopamine in inhibitory action control.
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| Keywords: | Response inhibition Dopamine Spontaneous eyeblink |
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