| CYP2D6基因与药物代谢 |
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| 引用本文： | 施安国. CYP2D6基因与药物代谢[J]. 中国新药与临床杂志, 2003, 22(8): 491-494 |
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| 作者姓名： | 施安国 |
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| 作者单位： | 上海第二医科大学附属仁济医院,药剂科、临床药学实验室,上海,200001 |
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| 摘 要： | 细胞色素P 45 0 (CYP)中的CYP2D6酶在抗抑郁药、安定药及某些抗心律失常药的代谢中起重要作用 ,CYP2D6基因位于 2 2号常染色体上为隐性遗传 ,CYP2D6基因呈多态性约有 70余种等位基因变异型 ,也存在特异人群差别 ,因而导致所编码的酶活性不同 ,这些数据有助于理解药物代谢的个体差异、有助于预测药物之间的相互作用。
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| 关 键 词： | 细胞色素P-450 药动学 多态现象(遗传学) 酶类 CYP2D6基因 |
| 文章编号： | 1007-7669(2003)08-0491-04 |
CYP2D6 gene and drug metabolism |
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| SHI An-guo. CYP2D6 gene and drug metabolism[J]. Chinese Journal of New Drugs and Clinical Remedies, 2003, 22(8): 491-494 |
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| Authors: | SHI An-guo |
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| Abstract: | CYP2D6 enzyme of cytochrome P-450(CYP) plays an important role in metabolism of antidepressants,neuroleptics, and some antiarrhythmics etc. The gene encoding of the enzyme is localized on chromosome 22 and inherited as an autosomal recessive trait. CYP2D6 gene is highly polymorphic with 70 allelic variants and has population-specific allelic variants which encode different enzyme activities. The data are helpful to understand interindividual variation in drug metabolism and to predict drug-drug interactions. |
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| Keywords: | cytochrome P-450 pharmacokinetics polymorphism(genetics) enzymes CYP2D6 gene |
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