| 转化生长因子α和p53基因在生殖器疣与癌中的表达 |
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| 引用本文： | 刘元林,刘荣卿. 转化生长因子α和p53基因在生殖器疣与癌中的表达[J]. 中国皮肤性病学杂志, 1998, 0(6) |
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| 作者姓名： | 刘元林 刘荣卿 |
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| 作者单位： | 北京海军总医院皮肤科(刘元林)，重庆第三军医大学一附院(刘荣卿) |
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| 摘 要： | 目的：探讨ｐ５３、ＴＧＦα及其受体ＥＧＦＲ在生殖器癌发生发展中的作用。方法：采用免疫组化方法检测上述基因在生殖器疣与癌中的表达。结果：生殖器癌中ｐ５３、ＴＧＦα及ＥＧＦＲ的阳性表达率分别为６３．３％（１９／３０）、９３．３％（２８／３０）和９０％（２７／３０），均非常显著高于生殖器疣。同时检测２３例癌中ＴＧＦα和ｐ５３蛋白之表达，显示２例ＴＧＦα阴性的病例，ｐ５３蛋白也未检测到。５例ＴＧＦα低表达者，其中４例ｐ５３阴性。ＥＧＦＲ和ｐ５３表达情况无明显关系。结论：提示ｐ５３、ＴＧＦα可能与生殖器癌的发生相关。
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| 关 键 词： | 生殖器疣 生殖器癌 转化生长因子α 基因.p~(53) |
Expression of transforming growth factor alpha and p53 in genital warts and cancers. |
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| Liu Yuanlin,Liu Rongqing. Expression of transforming growth factor alpha and p53 in genital warts and cancers.[J]. The Chinese Journal of Dermatovenereology, 1998, 0(6) |
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| Authors: | Liu Yuanlin Liu Rongqing |
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| Affiliation: | Liu Yuanlin,Liu Rongqing.Department of Dermatology,Navy General Hospital,Beijing,100037 |
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| Abstract: | Objective:In order to discuss the expression of p53、transforming growth factor(TGFα)and its receptor EGF R in the pathogenesis of genital cancer.Method We analyzed the expression of TGFα、EGF R and p53 in genital cancers by immunohistochemical technique.Results:Accumulation of p53、TGFα、and EGF R protein were found in 63.3%,93.3%,and 90.0% of carcinomas respectively.Meanwhile,the results of TGFα and p53 expression in 23 carcinomas showed that p53 protein was not detectable in 2 TGFα negative and 4 of 5 TGFα low expression cases.There was no relationship found between EGF R and p53 expression in these cases.Conclusion:p53 and TGFα expression may have some effects to the development of genital cancer. |
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| Keywords: | Genital warts Genital neoplasms femde TGFα Gene p53 |
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