|
|||||
|
|
| Patient education improves adherence to peg-interferon and ribavirin in chronic genotype 2 or 3 hepatitis C virus infection： A prospective, real-life, observational study | |
| 引用本文： | Cacoub P,Ouzan D,Melin P,Lang JP,Rotily M,Fontanges T,Varastet M,Chousterman M,Marcellin P. Patient education improves adherence to peg-interferon and ribavirin in chronic genotype 2 or 3 hepatitis C virus infection： A prospective, real-life, observational study[J]. World journal of gastroenterology : WJG, 2008, 14(40): 6195-6203. DOI: 10.3748/wjg:14.6195 |
| 作者姓名： | Cacoub P Ouzan D Melin P Lang JP Rotily M Fontanges T Varastet M Chousterman M Marcellin P |
| 作者单位： | 1. Department of Internal Medicine, Pitié-Salpêtrière Hospital, AP HP, Paris 75651, France; Pierre and Marie Curie (Paris 6) University, CNRS UMR 7087, Paris75651, France 2. Department of Hepato-Gastroenterology, Arnault Tzanck Institute, Saint Laurent du Var 06721, France 3. Department of Polyvalent Medicine, Hospital of Saint Dizier, Saint Dizier 52115, France 4. Department of Psychiatry and Addiction,Hospital of Erstein, Erstein 67152, France 5. ClinSearch, Bagneux 92220,France 6. Department of Hepato-Gastroenterology, General Hospital of Bourgoin, Bourgoin Jailleu 38317, France 7. Department of Hepato-Gastroentrology, Hospital of Créteil (CHIC), Créteil 94010, France 8. Department of Hepatology, Beaujon Hospital, Pole des Maladies de l'Appareil Digestif, Clichy 92118, France; and INSERMU 773, CRB3, University of Paris VII, Bcanjon Hospital, Clichy 92118, France |
| 基金项目： | Supported by Schering-Plough France |
| 摘 要： | AIM： To evaluate the impact of therapeutic education on adherence to antiviral treatment and sustained virological response （SVR） in a real-life setting in genotype 2/3 hepatitis C, as there are few adherence data in genotype 2/3 infection, even from randomized trials. METHODS： This prospective survey included genotype 2/3 patients who received peg-interferon alfa-2b and ribavirin. There was no intervention. Adherence wasself-reported over the past 4 wk （peg-interferon） or 7 d （ribavirin）. Adherence to bitherapy was defined as adherence to the two drugs for ≥ 20 wk. SVR was defined as undetectable RNA ≥ 12 wk after the end of treatment. RESULTS： 370/674 patients received education during the first 3 mo of treatment. After 6 too, adherence to bitherapy was higher in educated patients （61% vs 47%, P = 0.01）. Adherence to peg-interferon was 78% vs 69% （P=0.06）. Adherence to ribavirin was 70% vs 56% （P = 0.006）. The SVR （77% vs 70%, P = 0.05） and relapse （10% vs 16%, P = 0.09） rates tended to be improved. After adjustment for baseline differences, education improved adherence [Odds ratio （OR） 1.58, P = 0.04] but not the SVR （OR 1.54, P = 0.06）. CONCLUSION： In genotype 2/3 patients, therapeutic education helped maintain real-life adherence to bitherapy. |
| 关 键 词： | 肝炎病毒 治疗方法 干扰素 病毒唑 |
| 收稿时间： | 2008-06-19 |
Patient education improves adherence to peg-interferon and ribavirin in chronic genotype 2 or 3 hepatitis C virus infection: a prospective, real-life, observational study |
|
| Cacoub Patrice,Ouzan Denis,Melin Pascal,Lang Jean-Philippe,Rotily Michel,Fontanges Thierry,Varastet Marina,Chousterman Michel,Marcellin Patrick. Patient education improves adherence to peg-interferon and ribavirin in chronic genotype 2 or 3 hepatitis C virus infection: a prospective, real-life, observational study[J]. World journal of gastroenterology : WJG, 2008, 14(40): 6195-6203. DOI: 10.3748/wjg:14.6195 | |
| Authors: | Cacoub Patrice Ouzan Denis Melin Pascal Lang Jean-Philippe Rotily Michel Fontanges Thierry Varastet Marina Chousterman Michel Marcellin Patrick |
| Affiliation: | Department of Internal Medicine, Pitie-Salpetriere Hospital, 47-83 boulevard de l'Hopital, Paris cedex 13 F-75651, France. patrice.cacoub@psl.aphp.fr |
| Abstract: | AIM: To evaluate the impact of therapeutic education on adherence to antiviral treatment and sustained virological response (SVR) in a real-life setting in genotype 2/3 hepatitis C, as there are few adherence data in genotype 2/3 infection, even from randomized trials. METHODS: This prospective survey included genotype 2/3 patients who received peg-interferon alfa-2b and ribavirin. There was no intervention. Adherence was self-reported over the past 4 wk (peg-interferon) or 7 d (ribavirin). Adherence to bitherapy was defined as adherence to the two drugs for≥20 wk. SVR was defined as undetectable RNA≥12 wk after the end of treatment. RESULTS: 370/674 patients received education during the first 3 mo of treatment. After 6 mo, adherence to bitherapy was higher in educated patients (61% vs 47%, P=0.01). Adherence to peg-interferon was 78% vs 69% (P=0.06). Adherence to ribavirin was 70% vs 56% (P=0.006). The SVR (77% vs 70%, P = 0.05) and relapse (10% w 16%, P = 0.09) rates tended to be improved. After adjustment for baseline differences, education improved adherence [Odds ratio (OR) 1.58, P=0.04] but not the SVR (OR 1.54, P=0.06). CONCLUSION: In genotype 2/3 patients, therapeutic education helped maintain real-life adherence to bitherapy. |
| Keywords: | Viral hepatitis Adherence Therapeuticeducation Real life Peg-interferon Ribavirin |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ | |