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Protein kinase C in astrocytes: a determinant of cell morphology |
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| Authors: | Philip L. Mobley Sandra L. Scott Esther G. Cruz |
| Affiliation: | 1. Department of Pharmaceutics, SGT College of Pharmacy, SGT University, Budhera, Gurugram 122505, Haryana, India;2. Pharmacy College Saifai, Uttar Pradesh University of Medical Sciences, Saifai, Etawah 206130, Uttar Pradesh, India |
| Abstract: | Protein kinase C-like activity was found to be present in astrocytes prepared from rat neocortex and maintained in culture. Exposure to phorbol 12-myristate 13-acetate (PMA) caused a redistribution of this kinase from the cytosol to the membrane fraction of these cells. Also PMA was found to cause a profound change in astrocyte morphology; cells were converted from flat, polygonal, undifferentiated cells to process-bearing cells. |
| Keywords: | Astrocyte Phorbol ester Protein kinase C Astrocyte culture Cyclic adenosine monophosphate Differentiation |
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