| HPLC法测定盐酸地芬尼多片的含量 |
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| 引用本文： | 李季静,陈建,王丽琴. HPLC法测定盐酸地芬尼多片的含量[J]. 天津药学, 2009, 21(5): 5-7 |
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| 作者姓名： | 李季静 陈建 王丽琴 |
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| 作者单位： | 1. 天津市宝坻区药品检验所,天津,301800
2. 天津市药品检验所,天津,300070 |
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| 摘 要： | 目的：建立HPLC法测定盐酸地芬尼多片的含量。方法：色谱柱为Diamonsil C18（4.6 mm×150 mm,5μm）;甲醇-水-三乙胺（55∶45∶0.2）用磷酸调节至pH4.0为流动相,检测波长220 nm。结果：在12.4～37.2μg/ml范围内,溶液浓度与峰面积呈良好的线性关系（r=1.0000）;平均回收率为99.3%,RSD为1.1%（n=6）。结论：本方法简便、准确、可靠。
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| 关 键 词： | HPLC 盐酸地芬尼多 含量测定 |
Determination of Difenidol Hydrochloride by HPLC |
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| Li Jijing,Chen Jian,Wang Liqing. Determination of Difenidol Hydrochloride by HPLC[J]. Tianjin Pharmacy, 2009, 21(5): 5-7 |
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| Authors: | Li Jijing Chen Jian Wang Liqing |
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| Affiliation: | Li Jijing ,Chen Jian, Wang Liqing ( 1. Tianjin Baodi Institute for Drug Control, Tianjin 301800 ;2. Tianjin Institute for Drug Control, Tianjin 300070) |
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| Abstract: | Objective： To establish an HPLC method for the determination of difenidol hydrochloride tablets.Methods： The chromatographic system consisted of a C18 column as stationary phase and a solution of methanol-water-triethylamine（55∶45∶0.2）,pH of which was adjusted to 4.0 with phosphoric acid,as mobile phase.The detective wavelength was at 220 nm.Results： The linear range of difenidol hydrochloricde was 12.4～37.2 μg/ml（r=1.000 0）.The average recovery was 99.3%,and RSD 1.1%（n=6）.Conclusion： This method is simple,accurate, and reliable. |
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| Keywords: | HPLC |
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