The tryptolines: Effect of intraventricular administration on spontaneous motor activity of rats |
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| Authors: | RA Green JD Barchas GR Elliott JS Carman RJ Wyatt |
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| Institution: | 1. Laboratory of Clinical Psychopharmacology, Division of Special Mental Health Research, IRP, NIMH Saint Elizabeths Hospital, Washington D.C. 20032, USA;2. Laboratory of Behavioral Neurochemistry, Department of Phychiatry and Behavioral Science Stanford School of Medicine, Stanford, CA 94305, USA |
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| Abstract: | The pharmacologic properties of the tryptolines, hindered analogues of the tryptamines, were studied behaviorally in rats. Following intraventricular injections, it was found that spontaneous motor activity decreased markedly during the initial 25 mins when compared with saline. Since both the tryptolines and tryptamines have been shown to be inhibitors of 5-hydroxytryptamine uptake, it may be possible that these compounds are acting indirectly through an effect on the serotonergic system. |
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| Keywords: | Tryptolines Tryptamine 5-HT Serotonin Motor activity |
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