Exacerbation phenotyping in chronic obstructive pulmonary disease |
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| Authors: | Martin MacDonald Tony Korman Paul King Kais Hamza Philip Bardin |
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| Affiliation: | Monash Lung and Sleep, Monash Medical Centre, , Melbourne, Victoria, Australia |
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| Abstract: | Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are crucial events but causes remain poorly defined. A method to clinically ‘phenotype’ AECOPD have been proposed, and 52 hospitalized chronic obstructive pulmonary disease exacerbations according to underlying aetiology have now been prospectively phenotyped. Multiple exacerbation phenotypes were identified. A subpopulation coinfected with virus and bacteria had a significantly longer length of hospital stay, and this pilot study indicates that exacerbation phenotyping may be advantageous. |
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| Keywords: | clinical respiratory medicine chronic obstructive pulmonary disease emphysema infection and inflammation viral infection |
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