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Photoacoustic Imaging of the Bladder |
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| Authors: | Aya Kamaya MD Srikant Vaithilingam PhD Benjamin I. Chung MD Omer Oralkan PhD Butrus T. Khuri-Yakub PhD |
| Affiliation: | 1. Department of Radiology, Stanford University Medical Center, Stanford, California USA.;2. Stanford University, Stanford, California USA.;3. Department of Electrical and Computer Engineering, North Carolina State University, Raleigh, North Carolina USA.;4. E. L. Ginzton Laboratory, Center for Nanoscale Science and Engineering, Stanford University, Stanford, California USA. |
| Abstract: | Photoacoustic imaging is a promising new technology that combines tissue optical characteristics with ultrasound transmission and can potentially visualize tumor depth in bladder cancer. We imaged simulated tumors in 5 fresh porcine bladders with conventional pulse‐echo sonography and photoacoustic imaging. Isoechoic biomaterials of different optical qualities were used. In all 5 of the bladder specimens, photoacoustic imaging showed injected biomaterials, containing varying degrees of pigment, better than control pulse‐echo sonography. Photoacoustic imaging may be complementary to diagnostic information obtained by cystoscopy and urine cytologic analysis and could potentially obviate the need for biopsy in some tumors before definitive treatment. |
| Keywords: | bladder cancer bladder tumor depth bladder tumor staging noninvasive bladder cancer staging optoacoustic imaging photoacoustic imaging |