Liver transplantation for acute liver failure caused by macrophage activation syndrome |
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Authors: | James Orr Yvonne Bury Mark Hudson Steven Masson |
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Institution: | 1. Institute of Cellular Medicine, Newcastle University, , Newcastle upon Tyne, UK;2. Liver Unit, Freeman Hospital, , Newcastle upon Tyne, UK;3. Cellular Pathology, Royal Victoria Infirmary, , Newcastle upon Tyne, UK |
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Abstract: | Macrophage activation syndrome (MAS) is a rare, potentially fatal condition, which most frequently complicates rheumatological conditions and is often associated with liver dysfunction. In this case report of a patient with MAS, acute liver failure developed despite conventional immunosuppressive therapy. Liver transplantation resulted in rapid recovery and the patient has remained well for six years. A recent diagnosis of Adult Onset Still's Disease (AOSD) provides additional supporting evidence that the initial presentation was caused by MAS. While transplantation in the context of systemic disease remains controversial, this first reported case of successful adult liver transplantation for acute liver failure caused by MAS raises an interesting clinical dilemma. |
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Keywords: | acute liver failure adult onset still's disease liver transplantation macrophage activation syndrome |
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