TLR3、NF-κB在病毒性心肌炎心肌中的表达及意义

目的检测Toll样受体3（TLR3）和核因子-κB（NF-κB）在病毒性心肌炎（VMC）所致猝死者心肌组织中的表达，并探讨其意义。方法运用免疫组化SP法检测TLR3与NF-κB在VMC猝死者及非VMC对照组心肌组织中的表达．比较两组间的表达差异。结果病毒性心肌炎组心肌组织中TLR3、NF-κB的阳性细胞数为（12．2200±3．49249）和（28．3300±4．67435），分别高于对照组的（2．1750±0．93464）和（3．7900±1．43707），差异有统计学意义（P〈0．05），并且两种蛋白的表达量呈显著正相关（r=0．490，P〈0．05）。结论TLR3、NF-κB在VMC发生发展过程中起着重要作用，抑制TLR3、NF-κB的活化可能成为治疗VMC的一个潜在的、有价值的靶位。

Expression and significance of TLR3 and NF-κB in viral myocarditis

Objective To explore the expression and significance of Toll-like receptor 3 （TLR3） and nuclear factor-κB （NF-κB） in myoeardium of sudden death caused by viral myocarditis（VMC）. Method The expression levels of TLR3 and NF-κB of VMC group and control group were determined by immunohistoehemical technique （SP staining） and compared between two groups with statistical software. Result Compared with the control group, the expression levels of TLR3 and NF-κB of VMC group increased remarkably（P〈0.05） and showed a positive correlation （r=0.490,P〈0.05）. Conclusion TLR3 and NF-κB may play an important role in the genesis and development of viral myoearditis and could be used as the target for the treatment of viral myocarditis.