Periostin，NF-kB 蛋白在食管鳞癌组织中的表达及意义

目的：观察Periostin，NF-kB蛋白在食管鳞癌发生发展及侵袭转移过程中的作用。方法采用SP法分别对80例食管鳞癌组织，80例正常食管黏膜组织中Periostin，NF-kB蛋白的表达进行检测。结果 Peri-ostin，NF-KB在食管鳞癌的表达分别与浸润深度，分化程度、有无淋巴结转移有相关性，且两者的表达成正相关（ P＜0．05）。结论 Periostin与NF-kB的表达密切相关，可为食管鳞癌的治疗提供新的依据。

Expression and Significance of Periostin and NF-kB in the Tissue of Esophageal Carcinoma

Objective To investigate the effect of Periostin ,NF-kB protein in occurrence development and invasion and metastais in esophageal squamous cell cancinoma .Methods Immunohistochemical staining （ S-P method ） was used to detect Periostin and NF-kB expressions in 80 cases of esophageal carcinoma and 80 cases of normal .Results The expression of Periostin and NF-kB was related to the depth of invasion ,the degrees of differentiation ,and the me-tastasis of lymph node.The expression of Periostin was positively correlated withthe expression of NF-kB（P〈0.05）. Conclusion The expression of Periostin and NF-kB has a close relationship with the carcinogenesis and the develop-ment of esophageal squamous cell carcinoma , and which can provide the new evidence for the treatment of esophageal squamous cell carcinoma .