Predictors of vasomotor symptoms among breast cancer survivors |
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Authors: | Katherine W. Reeves Michael Pennell Randi E. Foraker Carolyn J. Crandall Marcia Stefanick Electra D. Paskett |
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Affiliation: | 1.Department of Biostatistics and Epidemiology,University of Massachusetts,Amherst,USA;2.Division of Biostatistics, College of Public Health,The Ohio State University,Columbus,USA;3.Division of Epidemiology, College of Public Health,The Ohio State University,Columbus,USA;4.Division of General Internal Medicine and Health Services Research, Department of Medicine,David Geffen School of Medicine at University of California, Los Angeles,Los Angeles,USA;5.Stanford Prevention Research Center,Stanford University School of Medicine,Stanford,USA;6.The Division of Cancer Prevention and Control,Ohio State University,Columbus,USA;7.The Ohio State University Comprehensive Cancer Center,Columbus,USA |
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Abstract: | PurposeVasomotor symptoms (VMS) are a common side effect of breast cancer treatment, yet modifiable factors that may predict VMS among breast cancer survivors are unknown.MethodsWe estimated multivariable-adjusted odds ratios and 95% confidence intervals (aOR, 95% CI) for predictors of VMS among 3595 breast cancer survivors enrolled in the Life and Longevity after Cancer (LILAC) study, an ancillary study of the Women’s Health Initiative (WHI).ResultsVMS post-diagnosis were reported by 790 (22.0%) participants. Risk of VMS after diagnosis was positively associated with prior chemotherapy (aOR 1.80, 95% CI 1.21–2.68) and adjuvant hormone therapy (aOR 2.73, 95% CI 2.08–3.58), postmenopausal hormone therapy use (aOR 1.67, 95% CI 1.30–2.13), prior VMS (aOR 2.20, 95% CI 1.73–2.80), bilateral oophorectomy (aOR 1.77, 95% CI 1.37–2.27), and baseline antidepressant use (aOR 1.49, 1.06–2.09). VMS post-diagnosis were less likely among younger women (aOR 0.94, 95% CI 0.93–0.96), women younger at menopause (aOR 0.98, 95% CI 0.97–1.00), women with more time since diagnosis (aOR 0.92, 95% CI 0.90–0.94), and diabetics (aOR 0.45, 95% CI 0.21–0.95). Metabolic syndrome was not associated with post-diagnosis VMS (aOR 0.76, 95% CI 0.45–1.28).ConclusionsVMS following breast cancer diagnosis was related to a number of modifiable factors, but was unrelated to metabolic syndrome.Implications for Cancer SurvivorsIdentification of factors that predispose women to VMS following a breast cancer diagnosis may allow clinicians to recognize and address VMS in the subset of women who are most likely to experience such symptoms. |
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