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Quality of life and pain relief in men with metastatic castration‐resistant prostate cancer on cabazitaxel: the non‐interventional ‘QoLiTime’ study
Authors:Ralf‐Dieter Hofheinz  Carsten Lange  Thorsten Ecke  Susanne Kloss  Burkhard Linsse  Christine Windemuth‐Kieselbach  Peter Hammerer  Salah‐Eddin Al‐Batran
Affiliation:1. University Hospital Mannheim, Mannheim, Germany;2. Private Practice, Bernburg, Germany;3. Helios Hospital, Bad Saarow, Germany;4. DRK Hospital, Luckenwalde, Germany;5. Sanofi‐Aventis Deutschland GmbH, Berlin, Germany;6. Alcedis GmbH, Gie?en, Germany;7. Academic Hospital Braunschweig, Braunschweig, Germany;8. Institute of Clinical Cancer Research, UCT – University Cancer Center, Frankfurt am Main, Germany
Abstract:Female urologists represent an ever‐increasing percentage of the work force; more and more of our colleagues will be working through pregnancy. There is a lack of clear and concise advice for pregnant urologists about occupational risks during pregnancy. Urology exposes expectant mothers to potential risks from radiation, teratogenic and cytotoxic drugs, iodine hand scrub, infections, and long working hours. We aim to provide a review of the current evidence and guidance to aid expectant mothers in their decision making. Relevant research articles and up‐to‐date guidance were reviewed. The millisevert (the average accumulated background radiation dose to an individual for 1 year, exclusive of radon) was used as the main unit of radiation dose. There is no published evidence to date in pregnant clinicians that shows a received radiation dose of more than the recommended dose for a pregnant lady, and no data showing an increased risk of foetal abnormalities in clinicians who continue to screen during pregnancy; however, the data are from small studies. There is strong advice suggesting avoidance of contact with crushed or broken 5α‐reductase inhibitor tablets (finasteride and dutasteride), mitomycin and other cytotoxic drugs during pregnancy. Pregnant surgeons should avoid frequent use of iodine hand wash. Good hygiene precautions will protect from many infections along with up‐to‐date immunisations and use of personal protective equipment for certain cases.
Keywords:cabazitaxel  metastatic castration‐resistant prostate cancer  prostate‐specific antigen  quality of life  survival
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