| 包头地区寻常性银屑病与HLA-Cw* 0602等位基因的相关性研究 |
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| 引用本文： | 白利平,闫秀兰,秦文斌,睢天林,王媚媚. 包头地区寻常性银屑病与HLA-Cw* 0602等位基因的相关性研究[J]. 中国皮肤性病学杂志, 2005, 19(2): 86-88 |
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| 作者姓名： | 白利平 闫秀兰 秦文斌 睢天林 王媚媚 |
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| 作者单位： | 1. 内蒙古科技大学包头医学院基因诊断研究所,内蒙古,包头,014010
2. 内蒙古科技大学第一附属医院皮肤性病科,内蒙古,包头,014010 |
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| 摘 要： | 目的探讨包头地区汉族寻常性银屑病患者与HLACw0602等位基因的相关性。方法采用聚合酶链反应序列特异引物(PCRSSP)法,检测52例寻常性银屑病患者及60名健康对照者的等位基因频率,并相互比较。结果①HLACw0602与包头地区汉族寻常性银屑病患者具有明显的相关性(OR=3.47,P<0.01);②HLACw0602在Ⅰ型、Ⅱ型寻常性银屑病患者中分布无差异(χ2=0.006,P>0.05)。结论HLACw0602可能是寻常性银屑病易感基因或与易感基因相连锁。
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| 关 键 词： | 银屑病 HLA-Cw* 0602 聚合酶链反应序列特异引物 |
| 文章编号： | 1001-7089(2005)02-0086-03 |
Investigation of Association of HLA- Cw*0602 Allele with Psoriasis Vulgaris in Han Nationality from Baotou Area |
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| BAI Li-ping,YAN Xiu-lan,QIN Wen-bin,et al. Investigation of Association of HLA- Cw*0602 Allele with Psoriasis Vulgaris in Han Nationality from Baotou Area[J]. The Chinese Journal of Dermatovenereology, 2005, 19(2): 86-88 |
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| Authors: | BAI Li-ping YAN Xiu-lan QIN Wen-bin et al |
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| Abstract: | Objective To study the association of HLA-Cw*0602 allele with genetic susceptibility to psoriasis vulgaris(PV) in the Han nationality from Baotou.Methods Using high-resolution polymerase chain reaction amplification with sequence specific primers(PCR-SSP),we detected the distribution frequencies of HLA-Cw*0602 allele among 52 patients with PV and 60 healthy controls,and compared witi each other.Results ①HLA-Cw*0602 allele was markedly correlated with psoriasis vulgaris from Baotou(P<0.01,OR=3.47);② There is no difference of distribution between patients with Ⅰtype and Ⅱtype psoriasis vulgaris (χ2=0.006,P>0.05).Conclusion HLA-Cw*0602 may be a susceptible gene or it may have close linkage with the susceptible gene in psoriasis vulgaris. |
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| Keywords: | Psoriasis HLA-Cw* 0602 PCR-SSP |
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