新药物新方案在晚期胃癌化疗中的应用

胃癌在中国发病率很高,但该病诊断时常为中晚期,化疗是综合治疗的重要组成部分。较最佳支持治疗而言,化疗可显著延长晚期胃癌患者生存期,提高生存质量。四十余年来,5-氟尿嘧啶、顺铂、表阿霉素等药物组成的二联或三联方案用于治疗晚期胃癌取得了一定疗效,晚近随着多西紫杉醇、伊立替康、草酸铂和卡培他滨等新药的应用,治疗效果进一步提高。而将西妥昔单抗和贝伐单抗等分子靶向药物与化疗合用,有望成为更具前景的治疗方案。

Novel drugs and novel regimens in treatment of advanced gastric cancer

There is a high prevalence of gastric cancer in China,but most of the patients are diagnosed at advanced stages,when chemotherapy is regarded as an important component of the multimodal treatment.Chemotherapy has demonstrated advantages over best suppor-tive care in prolonging survival and improving quality of life.Over the past 40 years,the clinical responses of two or three-drug combination chemotherapy regimens have been accepted,and 5-fluorouracil,cisplatin and epirubicin have been most frequently used in gastric cancer.Recently,the therapeutic effects of advanced gastric cancer treated by new regimen consisted of docetaxel,irinotecan,oxaliplatin and capecitabine have been further enhanced.The molecular targeted agent,cetuximab and bevacizumab,combined with chemotherapy,would be more promising therapeutic regimens in the treatment of advanced gastric caner.