| 三磷酸腺苷脂质体的研究进展 |
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| 引用本文： | 皮凤梅,屠锡德,周建平.三磷酸腺苷脂质体的研究进展[J].药学与临床研究,2007,15(1):1-5. |
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| 作者姓名： | 皮凤梅 屠锡德 周建平 |
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| 作者单位： | 中国药科大学药学院,南京,210009;中国药科大学药学院,南京,210009;中国药科大学药学院,南京,210009 |
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| 摘 要： | 本文综述了近年来三磷酸腺苷(ATP)脂质体的研究进展.脂质体作为新载体可以提高ATP在体内的稳定性,并且能靶向于缺血的心肌和缺血的大脑,用于器官移植中能提高冷冻贮存器官的能级状态,提高移植的成活率,故制备稳定的ATP脂质体具有重要的意义.本文还综述了ATP脂质体的制备方法,探讨如何进一步提高脂质体的包裹率和靶向性,以用于临床.
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| 关 键 词： | 三磷酸腺苷(ATP) 脂质体 包裹率 心肌靶向 脑靶向 肝靶向 |
| 文章编号： | 1673-7806（2007）01-01-05 |
| 收稿时间： | 2006-09-28 |
| 修稿时间： | 2006年9月28日 |
School of Pharm acy, China Pharm aceutical University, Nanjing 210009, China |
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| PI Feng-mei,TU Xi-de and ZHOU Jian-ping.School of Pharm acy, China Pharm aceutical University, Nanjing 210009, China[J].Pharmacertical and Clinical Research,2007,15(1):1-5. |
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| Authors: | PI Feng-mei TU Xi-de and ZHOU Jian-ping |
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| Institution: | School of Pharm acy, China Pharm aceutical University, Nanjing 210009, China,School of Pharm acy, China Pharm aceutical University, Nanjing 210009, China,School of Pharm acy, China Pharm aceutical University, Nanjing 210009, China |
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| Abstract: | This article reviews the recent development in ATP-loaded liposomes.As a new drug delivery vehicle,liposomes can improve in vivo the stability of ATP and accumulate in infracted cardiac muscle and ischemic cerebrum.Supply of liposomally-entrapped ATP during preservation of transplant organs will improve its energy state and metabolism.So to prepare stable ATP-loaded liposome is of great significance.In the second part,it reviews the preparation method of ATP-loaded liposomes and pursues the method of raise its encapsulation ratio and accumulation in targeted area,so as to use it clinically. |
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| Keywords: | Adenosine triphosphate(ATP) Liposomes Encapsulation ratio Cardiac muscle targeting Ischemic cerebrum targeting Livers targeting |
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