韦尼克脑病16例临床分析

目的探讨韦尼克脑病(Wernicke’s encephalopathy,WE)的病因、发病机制、临床表现及治疗。方法回顾性分析我院2002~2009年16例WE患者的临床资料。结果 WE病因复杂,饮酒为其最常见的病因。主要临床表现包括行走不稳、眼征、精神神志障碍三联征,但典型的WE三联征很少同时出现,往往以其中一种或两种表现为主。头部MRI大多为腔隙性脑梗死、脑萎缩等非特异性表现,丘脑、下丘脑、乳头体及脑室周围等部位对称性长T1、长T2信号的特征性表现并不多见。绝大多数患者经大剂量补充Vit-B1后疗效显著。结论 WE病因及临床表现复杂多样,早期诊断困难,头部MRI可作为WE重要的辅助检查。及时补充大剂量Vit-B1预后良好。

Clinical analysis of Wernicke's encephalopathy(report of 16 cases)

Objective To explore the etiology,pathogenesis,clinical manifestations and treatment of Wernicke's encephalopathy(WE).Methods All clinical date of 16 WE patients were reviewed retrospectively.Results Alcohol abuse was the major cause of WE.Ocular signs,cerebellar dysfunction and confusion were the most common and frequent symptoms of WE.However,the classical diagnostic triad was only found in 6.2%of patients.Lacunar infarction and brain atrophy were the most common findings on brain scan.The typical lesions...