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| 棓丙酯对大鼠急性脑缺血再灌注损伤的保护作用 | |
| 引用本文： | 吕首旭,贾洪丽,陈春光,孙丽红,徐长庆. 棓丙酯对大鼠急性脑缺血再灌注损伤的保护作用[J]. 中风与神经疾病杂志, 2011, 28(10) |
| 作者姓名： | 吕首旭 贾洪丽 陈春光 孙丽红 徐长庆 |
| 作者单位： | 1. 黑龙江省红十字医院神经内科,黑龙江哈尔滨,150040 2. 哈尔滨医科大学病理生理教研室,黑龙江哈尔滨,150056 3. 黑龙江省医院,黑龙江哈尔滨,150020 4. 中国人民解放军211医院,黑龙江哈尔滨,150086 |
| 摘 要： | 目的探讨棓丙酯注射液对大鼠急性脑缺血-再灌注损伤的保护作用及其可能机制。方法采用线栓法制备大鼠右侧大脑中动脉栓塞所致的缺血-再灌注模型。观测神经功能学评分、脑梗死面积、光镜和电镜下形态结构、超氧化物歧化酶活性及丙二醛含量变化。结果与模型组相比,棓丙酯注射液能降低大鼠急性脑缺血-再灌注后神经功能学评分、梗死面积、缺血区脑组织MDA含量,并且能够减轻脑组织形态学和超微结构损伤、升高SOD活性。结论棓丙酯注射液对大鼠急性局灶性脑缺血-再灌注损伤有保护作用,其机制可能与升高SOD活性、清除自由基有关。 |
| 关 键 词： | 棓丙酯 脑缺血 丙二醛 超氧化物歧化酶 大鼠 |
The protective effect of propyl gallate injection on acute cerebral ischemic reperfusion injury |
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| LV Shou-xv,JIA Hong-li,CHEN Chun-guang,et al.. The protective effect of propyl gallate injection on acute cerebral ischemic reperfusion injury[J]. Journal of Apoplexy and Nervous Diseases, 2011, 28(10) | |
| Authors: | LV Shou-xv JIA Hong-li CHEN Chun-guang et al. |
| Affiliation: | LV Shou-xv,JIA Hong-li,CHEN Chun-guang,et al.(Department of Neurology,Red Cross Hospital of Heilongnjiang Province,Harbin 150040,China) |
| Abstract: | Objective To study the protective effects and the possible mechanisms of propyl gallate injection on acute transient focal cerebral ischemic reperfusion injury in rats.Methods The rat model of focal cerebral ischemia for 2h/reperfusion for 2h was established by middle cerebral artery occlusion.Neurological deficit score,infracted volume,the SOD activity and content of MDA were measured,and the morphological changes were observed using HE staining and electron microscope.Results Compared with IR group,the ne... |
| Keywords: | Propylgallate Cerebral ischemia SOD MDA Rats |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |