| 脑缺血后处理对缺血再灌注脑组织线粒体通透性转换的影响 |
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| 引用本文： | 李富强,白宏英,娄季宇,曾志磊.脑缺血后处理对缺血再灌注脑组织线粒体通透性转换的影响[J].中风与神经疾病杂志,2011,28(9). |
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| 作者姓名： | 李富强 白宏英 娄季宇 曾志磊 |
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| 作者单位： | 郑州大学第二附属医院神经内科,河南郑州,450014 |
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| 摘 要： | 目的观察线粒体通透性转化在脑缺血后处理干预下的改变情况。方法采用SD大鼠局灶脑缺血模型,设立假手术组、缺血/再灌注组、缺血后处理组及延迟缺血后处理组。于大脑中动脉缺血30min,再灌注30min后检测脑组织中丙二醛含量和线粒体通透性转换的改变情况,再灌注24h后检测脑梗死面积。结果脑缺血后处理组脑梗死面积明显减少(P<0.05),脑组织中丙二醛含量减少(P<0.05),线粒体通透性转换减轻(P<0.05);延迟脑缺血后处理组与缺血再灌注组相比无明显改变。结论脑缺血后处理有明显的脑保护作用,但其保护作用有时间依赖性,其机制可能与抑制线粒体通透性转换孔开放有关。
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| 关 键 词： | 脑缺血后处理 脑缺血/再灌注损伤 线粒体通透性转换 |
Postconditioning attenuates cerebral ischemia-reperfusion injury by inhibiting mitochondrial permeability transition |
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| LI Fu-qiang,BAI Hong-ying,LOU Ji-yu,et al..Postconditioning attenuates cerebral ischemia-reperfusion injury by inhibiting mitochondrial permeability transition[J].Journal of Apoplexy and Nervous Diseases,2011,28(9). |
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| Authors: | LI Fu-qiang BAI Hong-ying LOU Ji-yu |
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| Institution: | LI Fu-qiang,BAI Hong-ying,LOU Ji-yu,et al.(Department of Neurology,The Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450014,China) |
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| Abstract: | Objective Ischemic postconditioning had a proven benefit in the experimental arena of brain ischemia-reperfusion.we tested the hypothesis that Ischemic postconditioning may modulate mPTP opening.Methods Eighty healthy male Sprague-Dawley rats were randomly divided into 4 groups:sham group(n=20),ischemia-reperfusion group(n=20),ischemic postconditioning group(n=20),and delayed ischemic postconditioning group(n=20).Anesthetized rats underwent 30 minutes of ischemia and 30 minutes of reperfusion.Ischemia-reper... |
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| Keywords: | Cerebral ischemia-reperfusion injury Mitochondrial permeability transition Ischemic postconditioning |
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