| 银杏叶片对衰老大鼠海马CREB表达影响的实验研究 |
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| 引用本文： | 王怀颖,郝岩君,张悦,辛海涛. 银杏叶片对衰老大鼠海马CREB表达影响的实验研究[J]. 中风与神经疾病杂志, 2011, 28(9) |
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| 作者姓名： | 王怀颖 郝岩君 张悦 辛海涛 |
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| 作者单位： | 河北大学基础医学院生化教研室,河北保定,071000 |
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| 基金项目： | 河北省卫生厅医学研究重点课题(08377) |
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| 摘 要： | 目的研究银杏叶片对衰老大鼠海马CREB、pCREB表达的影响。方法雄性Wistar大鼠分为青年对照组(3月龄)、老年对照组(13月龄)和银杏叶组(13月龄)。银杏叶组大鼠每日灌胃银杏叶片,其余两组动物灌胃等量蒸馏水,共8w。Morris水迷宫实验观察大鼠空间记忆能力变化,Western Blot检测海马CREB、pCREB表达。结果 (1)与青年对照组相比,老年大鼠逃避潜伏期延长,穿越平台次数及平台象限停留时间减少(P<0.05);与老年对照组比较,银杏叶组大鼠逃避潜伏期缩短,穿越平台次数增多,平台象限停留时间延长(P<0.05)。(2)老年对照组大鼠海马CREB、pCREB表达水平低于青年对照组(P<0.05);与老年对照组相比,银杏叶组大鼠海马CREB、pCREB表达上升(P<0.05)。结论银杏叶片可改善老龄大鼠空间记忆功能,其机制可能与上调海马CA1区CREB、PCREB有关。
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| 关 键 词： | 银杏叶提取物 衰老 大鼠 海马 环腺苷酸反应元件结合蛋白 |
Effects of extract of Ginkgo Biloba on the expression of CREB in hippocampus of aging rats |
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| WANG Huai-ying,HAO Yan-jun,ZHANG Yue,et al.. Effects of extract of Ginkgo Biloba on the expression of CREB in hippocampus of aging rats[J]. Journal of Apoplexy and Nervous Diseases, 2011, 28(9) |
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| Authors: | WANG Huai-ying HAO Yan-jun ZHANG Yue et al. |
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| Affiliation: | WANG Huai-ying,HAO Yan-jun,ZHANG Yue,et al.(Biochemistry Department,College of Basic Medicine,Hebei University,Baoding 071000,China) |
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| Abstract: | Objective To investigate effects of extract of Ginkgo biloba on expressions of CREB and pCREB in hippocampus of aging rats.Methods Male wistar rats were divided into three groups:young control group,old control group and EGb group.Rats in EGb group were treated with intragastric administration of EGb,while rats of the other two groups were treated with distilled water.The spatial learning and memory were evaluated by Morris water maze,and expressions of CREB and pCREB were detected by Western blot.Results C... |
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| Keywords: | Extract of Ginkgo biloba Aging Rat Hippocampus cAMP response element binding protein |
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