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The effects of parabiosis on serum and kidney glycosidase activities in spontaneously diabetic mice
Authors:H. Fushimi  K. Nonaka  S. Tarui  Y. Tochino  H. Kanaya
Affiliation:(1) Department of Medicine, Sumitomo Hospital, Nakanoshima, Osaka, Japan;(2) Second Department of Medicine, Osaka University School of Medicine, Fukushima, Osaka, Japan;(3) Shionogi Laboratory, Sagisu, Osaka, Japan
Abstract:Summary Spontaneously diabetic non-obese mice of the ICR strain were newly inbred in Shionogi laboratory, Japan. Animals became diabetic suddenly, more frequently and severely in females. Blood glucose levels were 452±73 mg/100 ml with serum insulin levels of < 1.0 mgrU/ml in the fed state. Parabiosis with normal control ICR mice for 2 weeks decreased the blood glucose level to 260±51 mg/ 100ml (P<0.01) and resulted in serum insulin levels of 46.0±18.0 mgrU/ml (P<0.01). Kidney homogenate beta-N-acetylglucosaminidase and beta-galactosidase activities were reduced in diabetic mice (42% and 44% decrease respectively) (P<0.025 and P<0.001), and restored almost to normal after 2 weeks of parabiosis. Renal agr-mannosidase activity was decreased 43% (P<0.001) in the diabetic mice but unaffected by parabiosis. Serum beta-N-acetylglucosaminidase, beta-galactosidase and agr-glucosidase activities were significantly increased in diabetic mice (179%; 233% and 58% increase respectively) (P<0.005, P<0.001 and P<0.001), and returned to normal with parabiosis.
Keywords:Spontaneously diabetic mice  non-obese diabetic mice  kidney glycosidase activities    /content/j81g461114083u13/xxlarge945.gif"   alt="  agr"   align="  BASELINE"   BORDER="  0"  >- &     /content/j81g461114083u13/xxlarge946.gif"   alt="  beta"   align="  MIDDLE"   BORDER="  0"  >-glycosidase  parabiosis  diabetic control  diabetes
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