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| 基质金属蛋白酶－2与大肠癌浸润转移的关系 | |
| 引用本文： | 陶雅军,陈英杰,任新,温冬青,张朝群.基质金属蛋白酶－2与大肠癌浸润转移的关系[J].大连医科大学学报,2002,24(4):247-249. |
| 作者姓名： | 陶雅军 陈英杰 任新 温冬青 张朝群 |
| 作者单位： | 1. 大连大学医学院,基础I教研室,辽宁,大连,116622;大连医科大学,病理学教研室,辽宁,大连,116027 2. 大连大学医学院,基础I教研室,辽宁,大连,116622 3. 大连医科大学,病理学教研室,辽宁,大连,116027 |
| 摘 要： | 目的 探讨基质金属蛋白酶－2（MMP－2）表达与大肠癌浸润转移的关系。方法 采用S－P免疫组织化学染色技术，检测30例大肠腺瘤，60例大肠癌组织MMP－2的表达情况。结果 MMP－2的表达率在大肠腺瘤中为26．67％，显著低于大肠癌中的86．7％（P＜0．05）；其表达与大肠癌的Dukes分期，分化程度，淋巴结转移和生存期均密切相关（P均＜0．05）。结论：MMP－2的检测可以成为临床判断大癌的恶性程度，转移及预后的重要参考指标。 |
| 关 键 词： | 基质金属蛋白酶－2 大肠癌 浸润转移 |
| 文章编号： | 1000-5676(2002)04-0247-03 |
| 修稿时间： | 2002年7月26日 |
Relationship of expression of matrix metaloproteinases 2 to invasion and metastasis of colorectal cancer |
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| TAO Ya-jun,CHEN Ying-jie,REN Xin,WEN Dong-qing.Relationship of expression of matrix metaloproteinases 2 to invasion and metastasis of colorectal cancer[J].Journal of Dalian Medical University,2002,24(4):247-249. | |
| Authors: | TAO Ya-jun CHEN Ying-jie REN Xin WEN Dong-qing |
| Institution: | Medical of College, Dalian University, Dalian 116622, China;Medical of College, Dalian University, Dalian 116622, China;Medical of College, Dalian University, Dalian 116622, China;Medical of College, Dalian University, Dalian 116622, China;Department of Pharmacology, Dalian Medical University, Dalian 116027, China |
| Abstract: | To investingate the role of the expression of matrix metaloproteinases 2 (MMP-2) in invasion and metastasis of colorectal cancer(CRC). The MMP-2 expression was studied immuneohistochemistrically in 30 specimens of colorectal adenoma and 60 specimens of CRC. The expression rates of MMP-2 were 26.67% in colorectal adenoma and 86.67% in CRC, the later was apparently higher than the former( P <0.001). The MMP-2 expression was significantly related to Dukes stage ,cellular dedifferentiation, metastasis of lymph node and poor prognosis. Conclusion] The detection of expression about MMP-2 may be helpful to judge the malignant behavier of colorectal carcinoma and prognosis of the patient. |
| Keywords: | colorectal cancer matrix metaloproteinases 2 invasion and metastasis |
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