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Effect of late prophylaxis in hemophilia on joint status: a randomized trial
Authors:M. J. Manco‐Johnson  B. Lundin  S. Funk  C. Peterfy  D. Raunig  M. Werk  C. L. Kempton  M. T. Reding  S. Goranov  L. Gercheva  L. Rusen  V. Uscatescu  M. Pierdominici  S. Engelen  J. Pocoski  D. Walker  W. Hong
Affiliation:1. University of Colorado Anschutz Medical Campus, Aurora, CO, USA;2. Lund University and Sk?ne University Hospital, Lund, Sweden;3. Spire Sciences, Inc., Boca Raton, FL, USA;4. ICON Medical Imaging, Warrington, PA, USA;5. Martin‐Luther‐Krankenhaus, Akademisches Lehrkrankenhaus der Charité – Universit?tsmedizin Berlin, Berlin, Germany;6. Emory University, Atlanta, GA, USA;7. University of Minnesota, Minneapolis, MN, USA;8. UMHAT Sveti Georgi and Medical University, Plovdiv, Bulgaria;9. UMHAT Sveta Marina, Varna, Bulgaria;10. S. C. SANADOR SRL, Bucharest, Romania;11. Institutul Clinic Fundeni, Bucharest, Romania;12. Hospital Ramos Mejia, Buenos Aires, Argentina;13. Bayer, Whippany, NJ, USA
Abstract:

Essentials

  • High‐quality data are lacking on use of prophylaxis in adults with hemophilia and arthropathy.
  • SPINART was a 3‐year randomized clinical trial of late/tertiary prophylaxis vs on‐demand therapy.
  • Prophylaxis improved function, quality of life, activity and pain but not joint structure by MRI.
  • Prophylaxis improves function but must start before joint bleeding onset to prevent arthropathy.
Keywords:arthropathy  clinical trial  hemophilia A  magnetic resonance imaging  prophylaxis  quality of life
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