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Modulating immunogenicity of factor IX by fusion to an immunoglobulin Fc domain: a study using a hemophilia B mouse model
Authors:D. Levin  H. A. D. Lagassé  E. Burch  S. Strome  S. Tan  H. Jiang  Z. E. Sauna  B. Golding
Affiliation:1. Hemostasis Branch, Division of Plasma Protein Therapeutics, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA;2. Department of Otorhinolaryngology–Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD, USA;3. CRISPR Therapeutics, Cambridge, MA, USA;4. Editas Medicine, Cambridge, MA, USA;5. Plasma Derivatives Branch, Division of Plasma Protein Therapeutics, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA
Abstract:
Keywords:factor IX  Fc receptors  hemophilia B  immunoglobulin Fc fragment  Th1‐Th2 balance
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