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Dosing algorithms for vitamin K antagonists across VKORC1 and CYP2C9 genotypes
Authors:E. V. Baranova  T. I. Verhoef  G. Ragia  S. le Cessie  F. W. Asselbergs  A. de Boer  V. G. Manolopoulos  A. H. Maitland‐van der Zee  the EU‐PACT group
Affiliation:1. Department of Pharmaceutical Sciences, Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht University, Utrecht, the Netherlands;2. Department of Applied Health Research, University College London, London, UK;3. Laboratory of Pharmacology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece;4. Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, the Netherlands;5. Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands;6. Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands;7. Durrer Center for Cardiogenetic Research, ICIN‐Netherlands Heart Institute, Utrecht, the Netherlands;8. Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK;9. Department of Respiratory Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
Abstract:
Keywords:acenocoumarol  drug dosing biomarkers  pharmacogenetics  phenprocoumon  randomized controlled trial
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