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Absence of Trypanosoma cruzi myocardial infection reactivation in Chagas' heart transplant |
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| Authors: | Reinaldo B Bestetti MD PhD Oswaldo T Castilho MD PhD Luiz AC Teno MD Olavo C Freitas MD |
| Institution: | a Department of Pathology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil b Heart Institute of the Santa Casa Hospital, Ribeirão Preto, S.P., Brazil |
| Abstract: | The risk of Trypanosoma cruzi myocardial infection reactivation after immunosuppressive therapy has led to precluding heart transplantation as a therapeutic procedure for patients with end-stage Chagas' heart disease. We report a case of an orthotopic heart transplantation in a 43-year-old critically ill chagasic patient with an uneventful postoperative period. He was treated with azathioprine and cyclosporine to control graft rejection and showed no reactivation of the chagasic infection. One year following surgery, the patient is doing well. Nonsteroidal therapy appears not to reactivate T. cruzi infection in transplant chagasic patients. |
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